Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium - possible mechanism of action

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Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium--possible mechanism of action.

The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1.0 mg/mL) relaxation of spontaneous and high K(+) (80 mM)-induced contractions in isolated rabbit jejunum preparations, suggesting a Ca(++) antagonistic effect, which was confirmed when pretreatment of the tissue with Ho.Cr produced a rightward sh...

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acute and chronic effects of ferula persica on blood pressure of hypertensive rats and its possible mechanism of action

background: ferula persica has been used in traditional medicine for treatment of high blood pressure. in this study acute and chronic effect of aqueous f. persica extract on bp of hypertensive rats and its possible mechanism of action have been investigated. methods: eighty two male wistar rats were divided into 12 experimental groups. hypertension was induced by goldblatt method in the anesth...

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ژورنال

عنوان ژورنال: Phytotherapy Research

سال: 2009

ISSN: 0951-418X

DOI: 10.1002/ptr.3067